In article number 2007458, Meganne Christian, Raffaello Mazzaro, and Vittorio Morandi analyze the bioinspired design of graphene-based materials. The molecular structure of graphene resembles a natural honeycomb; moreover, thanks to the versatility of this amazing 2D material, it can also be shaped into honeycomb-like microstructures with wide-ranging applications such as next-generation electronics and sensing. Honeycomb is just one of the myriad natural structures, functions, and processes that can be used as inspiration for exciting new functional materials based on graphene.