Bismuth chalcogenides have a groundbreaking impact on materials science because of their potential applications in spintronics and optoelectronics, especially for their properties as topological insulators. Investigation of the biocompatibility of the electrode material at the tissue/electrode interface is essential to assess the use of topological insulators in bioelectronics. Here, we addressed the biocompatibility of Bi 2 Se 3 by demonstrating that porcine primary mixed retinal cells can survive on its surface with or without poly-D-lysine/laminin coating. Neuronal and glial cell survival were demonstrated using cell culture and imaging techniques. These results highlight the promising potential of Bi 2 Se 3 for integration into bioelectronic devices, particularly for the development of neural interfaces and other biomedical applications.