Microneedle devices could play the role of a painless door to the human body. These devices enable high performance in both drug delivery and diagnostic analysis. While there has been a strong effort by the healthcare industry and applied research laboratories, the microneedles platform has not yet reached commercial success in the global market. In this competitive frame, the simplest fabrication processes and the best performing products will rise to the top of the market. In article number 1900036, Luca De Stefano and co‐workers review recent advances in this field.